简介
朱永坚，男，主任医师，博士生导师,中华医学会神经外科学分会脊髓脊柱专业组委员、中华医学会神经外科学分会青年委员、中国医师协会脊髓脊柱分会委员、中国医促会骨科分会脊柱内镜专业委员会委员、浙江省医学会神经外科学分会常务委员、浙江省医师协会神经外科学分会常务委员。从事神经外科脊柱脊髓亚专科临床工作十余年，13年晋升主任医师，近年来年均脊柱脊髓专项手术量400余台次，主要致力于脊髓肿瘤，包括长节段髓内肿瘤、绝大椎管内外肿瘤、复发性肿瘤及脊髓血管畸形的显微手术，国内最早的椎板成形＋复位重建手术的提倡者，可避免术后的脊柱融合固定；同时也是经椎板间隙（微骨孔）入路切除椎管内肿瘤的首创和推行者。14年起开展经皮脊柱内镜治疗颈、腰椎间盘突出手术，并完成十余例经皮内镜下的脊髓肿瘤切除手术，相关领域国际领先。获多项国家自然科学基金及省重点研发项目基金支持，主持脊髓损伤与保护的基础研究以及脊柱脊髓微创手术的无辐射导航研究两个研究团队。第一作者或通讯作者发表文章：1. Tian-jian Liu, Fang Shen, Chao Zhang, Pin-tong Huang, Yong-jian Zhu*.Real-time ultrasound-MRI fusion image virtual navigation for locating intraspinal tumour in a pregnant woman, European Spine Journal,accepted. Published online:30 January 2018.doi:10.1007/s00586-017-5442-72. Guang-Yu Ying,Ying Yao,Fang Shen,Zong-YangWu,Chien-Min Chen,Yong-Jian Zhu*, Percutaneous Endoscopic Removal of Cervical Foraminal Schwannoma via Interlaminar Approach:A Case Report. Operative Neurosurgery 14:E1–E5, 2018 DOI: 10.1093/ons/opx0883. Ying GY, Yao Y, Shen F, Ren YC, Chen CM, Zhu YJ*.Percutaneous Endoscopic Removal of a Lumbar Epidural Angiolipoma via Interlaminar Approach: A Technical Report.World Neurosurg. 2017;99:59-62. doi: 10.1016/j.wneu.2016.11.088. Epub 2016 Nov 24.4. Wang C, Chen CM, Shen F, Fang XD, Ying GY, Ren YC, Yu DF, Zhu LL, Zhu YJ*, Zhang JM.Microscope-assisted endoscopic interlaminar ligation of spinal arteriovenous fistulas: technical note.J Neurosurg Spine. 2016 Sep;25(3):394-7. doi: 10.3171/2015.12.SPINE15366. Epub 2016 Apr 15.5. Zhu YJ#, Ying GY, Chen AQ, Wang LL, Yu DF, Zhu LL, Ren YC, Wang C, Wu PC, Yao Y, Shen F, Zhang JM.Minimally invasive removal of lumbar intradural extramedullary lesions using the interlaminar approach.Neurosurg Focus. 2015 Aug;39(2):E10. doi: 10.3171/2015.5.FOCUS15182.6. Wang J, Li H, Ren Y, Yao Y, Hu J, Zheng M, Ding Y, Chen YY, Shen Y, Wang LL*, Zhu YJ*. Local Delivery of β-Elemene Improves Locomotor Functional Recovery by Alleviating Endoplasmic Reticulum Stress and Reducing Neuronal Apoptosis in Rats with Spinal Cord Injury. Cell Physiol Biochem. 2018 Aug 30;49(2):595-609. doi: 10.1159/000492996. [Epub ahead of print]7. Wang J, Li H, Yao Y, Ren Y, Lin J, Hu J, Zheng M, Song X, Zhao T, Chen YY, Shen Y, Zhu YJ*, Wang LL*. β-Elemene Enhances GAP-43 Expression and Neurite Outgrowth by Inhibiting RhoA Kinase Activation in Rats with Spinal Cord Injury. Neuroscience. 2018 Jul 15;383:12-21. doi: 10.1016/j.neuroscience.2018.04.045. Epub 2018 May 9.8. Wang J, Li H, Yao Y, Zhao T, Chen YY, Shen YL, Wang LL*, Zhu YJ*. Stem cell-derived mitochondria transplantation: a novel strategy and the challenges for the treatment of tissue injury. Stem Cell Res Ther. 2018 Apr 13;9(1):106. doi: 10.1186/s13287-018-0832-2.9. Liansheng Gao, Weilin Xu, Shuangbo Fan, Tao Li, Tengfei Zhao,Guangyu Ying, Jingwei Zheng, Jianru Li, Zhongyuan Zhang, Feng Yan, Yongjian Zhu*,Gao Chen*. MANF attenuates neuronal apoptosis and promotes behavioral recovery via Akt/ MDM-2/p53 pathway after traumatic spinal cord injury in rats. Biofactors. 2018 May 24. doi: 10.1002/biof.1433. [Epub ahead of print]10. Ying Yao,Fang Shen,Aiqin Chen, Guangyu Ying, Yongjian Zhu*. Percutaneous endoscopic removal of a residual foreign body at the orbital-cranial region after transorbital penetrating injury: a novel minimally invasive technique. Chinese Neurosurgical Journal, (2017) 3:38,1-4.DOI 10.1186/s41016-017-0102-711. Yong-Jian Zhu#, De-Qing Peng, Fang Shen, Lin-Lin Wang, Zhu-Xiao Tang and Jian-Min Zhang. Spontaneous thoracic ventral spinal subdural hematoma mimicking a tumoral lesion: a case report. Journal of Medical Case Reports (2015) 9:132-135 DOI 10.1186/s13256-015-0562-312. Peng D, Zhu Y*. External drains versus no drains after burr-hole evacuation for the treatment of chronic subdural haematoma in adults.Cochrane Database Syst Rev.2016 Aug 31;(8):CD011402. doi: 10.1002/14651858.13. Zong-Yang Wu, Yong-Jian Zhu, Lei Chu, Chun-Yuan Cheng, Chien-Min Chen, Hsu Hui-Ting. Full-endoscopic transforaminal approach for removal of a spontaneous spinal epidural hematoma: A case report. World Neurosurgery (2016), doi: 10.1016/j.wneu.2016.07.086.14. Zhu Y#, Jin W, Liu H, Peng D, Ding, Tang Z, Zhu L, Yu Y.Effects of electromagnetic fields from mobile phones on depression and anxiety after titanium mesh cranioplasty among patients with traumatic brain injury. Brain Inj. 2016;30(1):66-73. doi: 10.3109/02699052.2015.1089594. Epub 2015 Nov 23.15. Wang Z, Fei Y, Liu H, Zheng S, Ding Z, Jin W, Pan Y, Chen Z, Wang L, Chen G, Xu Z, Zhu Y, Yu Y. Effects of electromagnetic fields exposure on plasma hormonal and inflammatory pathway biomarkers in male workers of a power plant.Int Arch Occup Environ Health. 2016 Jan;89(1):33-42. doi: 10.1007/s00420-015-1049-7. Epub 2015 Mar 26.16. Zhu Y#, Hu J, Shen F, Shen H, Liu W, Zhang J. The cytotoxic effect of β-elemene against malignant glioma is enhanced by base-excision repair inhibitor methoxyamine. J Neurooncol. 2013 Jul;113(3):375-84.17. Yongjian Zhu#, Jue Hu, Yiduo Hu, Weiguo Liu. Targeting DNA repair pathways: A novel approach to reduce cancer therapeutic resistance. Cancer Treat Rev(2009), Volume 35, Issue 7, November 2009, Pages 590-596 (2009 IF=5.32)18. Y Zhu#, F Gao, W Liu, et al. The Effect of Microwave Emission from Mobile Phones on Neuron Survival in Rat Central Nervous System. Progress In Electromagnetics Research, PIER 82, 287-298, 2008.(2008 IF=4.735)19. Yongjian Zhu#, Xiangdong Zhu, Hong Shen, et al. A Multivariate Analysis of the Prognostic Factors of grade III gliomas, Chinese Medical Journal 2008;121(12) :1072-1075 (2008 IF=0.858)20. 汪靖宇，刘天健，王琳琳，朱永坚*。急性脊髓损伤临床治疗进展，中华急诊医学杂志，2017，4（26），470-472.21. 彭德清，应广宇，朱亮亮，余丹枫，朱永坚*。急性自发椎管内血肿临床诊治及预后分析[J]. 中华急诊医学杂志，2016， 25(4):486-490.22. 朱永坚#，汤朱骁，王琳琳，朱亮亮，沈宏，张建民。经半-半椎板入路显微手术切除椎管内髓外膜内肿瘤，中华神经外科杂志，2014，30(7)，694-697.23. 朱永坚#，沈宏，张建民，刘伟国，陶祥洛. 一种改良的椎板成形、椎管重建术，浙江创伤外科杂志；2010.224. 朱永坚#，胡珏，许东航，吕庆华，刘伟国. 纳米脂质体承载榄香烯诱导C6胶质瘤细胞凋亡的实验研究，中国中西医结合杂志；2008.7
擅长
脊髓肿瘤的微创手术治疗及颈、腰椎间盘突出的内镜手术
