简介
王坚，男，临床医学博士，教授/主任医师，博士研究生导师。复旦大学附属华山医院神经内科副主任。美国匹兹堡大学“帕金森病及其它神经变性病研究中心”博士后。长期聚焦帕金森病临床及基础研究、慢病长程管理。
社会任职
1.国际帕金森病及运动障碍协会(MDS) “Web Editorial Board”专家委员会委员2.国家神经疾病医学中心(华山)功能神经疾病中心主任，3.国家老年疾病临床医学研究中心(华山)“神经退行性疾病”研究方向负责人4.中华医学会神经病学分会全国委员5.中国康复医学会帕金森病和运动障碍专业委员会副主任委员6.“中国e帕联盟”及“帕为帕金森病慢病管理APP平台”理事长
获奖荣誉
亚太MDS-AOS 2019 AOPMC年会Blue Ribbon Highlight奖
科研成果
共发表SCI文章119篇，论文共被引用3281次，H指数34(Google Scholar)。2020年以来以通讯/第一（含共同）作者发表SCI研究成果28篇，其中IF＞10共9篇[Brain(2), JAMA Neurol, Cell Res, Nat Commun, Mov Disord(3)]。主持重大(培育)、面上、青年等国自然基金共7项，主持科技部国家重点研发计划“重大慢性非传染性疾病防控研究”重点专项“帕金森病分子影像学研究”、 国家卫健委国家临床重点专科建设项目-功能神经疾病智能综合管理和诊疗体系建设、及多项省部级课题。2020年以来发表的部分代表性成果：1. Shen Y#, Yu WB#, Shen B#, Dong H, Zhao J, Tang YL, Fan Y, Yang YF, Sun YM, Luo SS, Chen C, Liu FT, Wu JJ, Xiao BG, Yu H, Koprich JB*, Huang ZL*, Wang J*. Propagated α-synucleinopathy recapitulates REM sleep behaviour disorder followed by parkinsonian phenotypes in mice. Brain 2020. 143:3374-3392. 2. Zhou XY#, Lu JY#, Liu FT, Wu P, Zhao J, Ju ZZ, Tang YL, Shi QY, Lin HM, Wu JJ, Yen TC, Zuo CT*, Sun YM*, Wang J*. In Vivo 18F‐APN-1607 Tau Positron Emission Tomography Imaging in MAPT Mutations: Cross‐Sectional and Longitudinal Findings. Mov Disord 2022, 37:525-534. 3. Fan Y#, Zhao Q#, Xia W, Tao Y, Yu W, Chen M, Liu Y, Zhao J, Shen Y, Sun Y, Si C, Zhang S, Zhang Y, Li W, Liu C*, Wang J*, Li D*. Generic amyloid fibrillation of TMEM106B in patient with Parkinson's disease dementia and normal elders. Cell Res 2022,0:1-4. 10.1038/s41422-022-00665-3. 4. Wu P#, Zhao Y#, Wu J, Brendel M, Lu J, Ge J, Bernhardt A, Li L, Alberts I, Katzdobler S, Yakushev I, Hong J, Xu Q, Sun Y, Liu F, Levin J, Hoeglinger G, Bassetti C, Guan Y, Oertel WH, Weber WA, Rominger A, Wang J*, Zuo C*, Shi K. Differential diagnosis of parkinsonism based on deep metabolic imaging indices. J Nucl Med 2022. 10.2967/jnumed.121.263029. 5. Li L#, Liu FT#, Li M, Lu JY, Sun YM, Bao WQ, Chen QS, Li XY, Zhou XY, Guan YH, Wu JJ, Yen TC, Jang MK, Wang J*, Zuo CT*, and the Progressive Supranuclear Palsy Neuroimage Initiative (PSPNI). Clinical utility of 18F-APN-1607 tau PET imaging in patients with progressive supranuclear palsy. Mov Disord 2021,36:2314-2323 6. Sun YM#, Yu HL#, Zhou XY, Xiong WX, Luo SS, Chen C, Liu FT, Zhao J, Tang YL, Liang XL, Yang YJ, Shen B, Shen Y, Yu WB, Ding ZT, An Y*, Wu JJ*, Wang J*. Disease Progression in Patients with Parkin-related Parkinson's Disease in a Longitudinal Cohort. Mov Disord 2021;36:442-448. 7. Liu FT, Wang J*, Chen Y*: Lost Dopaminergic Bindings in the Caudate of a Patient With Frontotemporal Lobar Degeneration-Motor Neuron Disease. JAMA Neurol 2020, 77:1448-1449. 8. Guo M#, Wang J#, Zhao Y, Feng Y, Han S, Dong Q*, Cui M*, Tieu K: Microglial exosomes facilitate alpha-synuclein transmission in Parkinson's disease. Brain 2020. 143:1476-1497. 9. Lou MM, Tang XQ, Wang GM, He J, Luo F, Guan MF, Wang F, Zou H, Wang JY, Zhang Q, Xu MJ, Shi QL, Shen LB, Ma GM, Wu Y, Zhang YY, Liang AB, Wang TH, Xiong LL, Wang J*, Xu J*, and Wang WY*. Long noncoding RNA BS-DRL1 modulates the DNA damage response and genome stability by interacting with HMGB1 in neurons. Nat Commun 2021, 12: 4075-4092.
擅长
帕金森病、帕金森综合征(进行性核上性麻痹，多系统萎缩等）、特发性震颤、肌张力障碍、抽动症、舞蹈症、肝豆状核变性等运动障碍病。
